JAMA. 1952;149(8):762-763. doi:10.1001/jama.1952.02930250044016.
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Weinstein1 reported in 1947 five cases in which, during the course of specific antibiotic therapy, there developed new infections due to organisms that were not susceptible to the agent being used for the primary disease. It appeared that when one group of organisms is suppressed others that are present may multiply more rapidly, invade tissue, and cause a superinfection. Harris,2 in 1950, reported on 91 female patients and 44 male patients treated with aureomycin and/or chloramphenicol for chronic brucellosis. These antibiotics, while effective in accomplishing a cure of brucellosis, produced in a large percentage of female patients and in a much smaller percentage of male patients side-effects of a type and severity not previously reported. Nausea, vomiting, epigastric distress, heartburn, and diarrhea occurred in 60.7% of the female patients and in 19.3% of the male patients. The frequency and the severity of gastrointestinal symptoms were greater with aureomycin


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