We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......


Ralph G. Greenlee, M.D.; Raleigh R. White, M.D.; Charles Phillips, M.D.
JAMA. 1952;149(3):272-273. doi:10.1001/jama.1952.72930200015011h.
Text Size: A A A
Published online


Shortly after the discovery of insulin by Banting and Best1 in 1922, it became apparent that severe hypoglycemia results from excessive administration of the drug. In 1924, Harris2 postulated the clinical syndrome of hyperinsulinism. It remained for Wilder and his coworkers3 to establish, in 1927, the unquestionable correlation between islet cell tumor of the pancreas and hyperinsulinism. Further evidence of the entity was offered in 1929 by Howland and his colleagues4 of Toronto, who removed an islet cell tumor from a patient with hyperinsulinism. As a result of increasing awareness of the clinical syndrome, Howard, Moss, and Rhoads,5 by 1950, were able to find recorded in the literature 264 cases of islet tumor with hyperinsulinism. The great majority of patients with this condition are adults, although the syndrome may occur at any age. Sherman6 reported the case of a baby girl with uncontrollable hypoglycemia


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.