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Leon Goldman, M.D.
JAMA. 1952;149(3):265. doi:10.1001/jama.1952.72930200008011d.
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Studies on the local effect of the oxysteroids have been under way in the department of dermatology and syphilology for some time. Previous studies1 with local application and local injection of cortisone acetate and a water soluble ester of cortisone had produced no constant positive results in a large series of clinical cases nor did the detailed animal experiments of Nilzen.2 This is contrary, of course, to the brilliant results obtained locally in diseases of the eye. Preliminary studies,3 however, with compound F have already revealed significant evidences of a local effect. Gibson4 has indicated that compound F has more local activity than cortisone. The following case is reported in order to show the definite and prolonged inhibitory local effect of compound F on severe reactions to mosquito bites.

REPORT OF CASE  The patient was a 46-year-old physician with a history of reaction to bites of


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