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Israel Zeligman, M.D.
JAMA. 1952;149(3):263-264. doi:10.1001/jama.1952.72930200006011c.
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At the First Clinical ACTH Conference, attention was drawn for the first time to allergic phenomena produced by the administration of corticotropin (ACTH). Traeger1 reported to the conference on allergic reactions in 4 of 19 patients treated with this drug. At the same meeting Markson2 and Stillman and Bayles3 reported one case each of sensitivity to the administration of this animal extract. At the Second Clinical ACTH Conference, Brown and Hollander4 reported a hypersensitivity reaction in 7 of 208 patients treated, which appeared to be due to the administration of corticotropin. In four of these seven patients the reactions were of serious proportions, necessitating withdrawal of corticotropin therapy. Intradermal testing with 0.1 cc. of a 1:10,000 dilution of pork corticotropin, in four patients with allergic symptoms, was positive. When these persons were treated with beef corticotropin, there were no allergic manifestations, and they had negative reactions


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