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Seymour S. Cutler, M.D.; Benjamin Burbank, M.D.; E. R. Marzullo, M.D.
JAMA. 1952;148(10):863-864. doi:10.1001/jama.1952.02930100081027.
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To the Editor:—  Our paper on "Hypocoagulability of Certain Irradiated Plasmas," in The Journal, July 22, 1950, page 1057, has provoked a "reinvestigation" of our work by Kaplan and Friedman ("Effects of Ultraviolet-Ray Irradiation on Clotting Mechanism of Plasma," J. A. M. A.147:229 [Sept. 15] 1951), in which they conclude that our ideas are erroneous and our conclusions untenable. We wish now to compare our original statements and the data of Kaplan and Friedman, which supposedly refute our findings.We examined the coagulability of various lots of human plasmas, irradiated, unirradiated, fresh, lyophilized, and plasma stored in liquid form. Irradiated liquid plasma, prepared and distributed by the Michael Reese Research Foundation, could not be coagulated by thrombin, even when applied in great concentrations. We stated that this phenomenon is due to the effect of ultraviolet irradiation. Kaplan and Friedman challenge this statement and set up two experiments to


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