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CATION EXCHANGE RESINS AS AN ADJUNCT IN TREATMENT OF HEART FAILURE

J. Edwin Wood Jr., M.D.; Donald H. Ferguson, M.D.; Preston Lowrance, M.D.
JAMA. 1952;148(10):820-824. doi:10.1001/jama.1952.02930100038008.
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Restriction of sodium in the diet has been accepted as helpful in the management of many patients with congestive heart failure and certain patients with other forms of edema, but the ideal sodium intake cannot always be accomplished by diet alone. In 1946, Dock1 suggested that a cation resin could be used to remove sodium, potassium, calcium, and magnesium from ingested foods and further indicated that such a resin was nontoxic for dogs and rats. Extensive studies in animals2 have demonstrated further the absence of toxicity from cation resins over short and long periods. These observers find that prolonged administration of the ammonium form of resin has not interfered with health, nutrition, or hematological development of animals. A detailed review3 of the literature on ion exchange resins and edema discusses fully the rationale for the use of these substances.

A cation exchange resin can also restrict the absorption of sodium from the human intestine,4 and its use has been found practical and effective in man.4b,d The

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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