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TERRAMYCIN IN EPIDEMIC TYPHUS, AMEBIC DYSENTERY, AND TYPHOID

John H. Killough, M.D.; Gordon B. Magill, M.D.
JAMA. 1951;147(18):1737-1740. doi:10.1001/jama.1951.03670350017005.
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Terramycin, introduced one year ago, has been tried and found successful in the treatment of an extensive array of human diseases. Its usefulness in epidemic typhus, acute amebic dysentery, and typhoid, however, has not yet been established. This report presents the results of treatment in five patients with epidemic typhus, seven patients with acute amebic dysentery, and five patients with typhoid. The findings suggest that in epidemic typhus terramycin is curative and that in acute amebic dysentery it is efficacious but has definite limitations. In typhoid, contrary to reports of failure to date, terramycin may elicit a favorable response in some patients.

Snyder and his colleagues1 in experiments with chick embryos found that terramycin suppressed the multiplication of Rickettsia prowazeki, but in studies on infected cotton rats the same authors were unable to obtain survival. Reports of trials in epidemic typhus in humans have not yet come to our

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