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COMPARISON OF EFFICACY OF VARIOUS DRUGS IN TREATMENT OF EPILEPSY

Elinor R. Ives, M.D.
JAMA. 1951;147(14):1332-1335. doi:10.1001/jama.1951.03670310022008.
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The patients in this study on the comparison of the efficacy of various drugs in the treatment of epilepsy attended the Los Angeles General Hospital outpatient department. Altogether 1,064 charts were reviewed. Of these, the records of only 212 patients seemed adequate for this study. Ages of the patients ranged from less than 1 year to 80 years, with over one-half between 21 to 50 years old, and about one-quarter under 21. The length of time over which seizures had been experienced varied from less than 1 year to over 62 years, with one-quarter of the patients having had seizures over 15 years, and more than one-half, over 6 years.

ETIOLOGY  There was significant evidence of an organic lesion in 104 patients, and of familial incidence in 11. In the remaining 97 patients etiology could not be definitely established. Of the 104 patients with organic pathology, in 10 the pathology

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