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Francis J. Lovelock, M.D.; Daniel J. Stone, M.D.
JAMA. 1951;147(10):930-932. doi:10.1001/jama.1951.03670270020008.
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Boeck's sarcoid is an inflammatory response to an unknown agent. As ordinarily seen and diagnosed in hospital practice, it is a chronic granuloma without significant necrosis. When the pulmonary disease has existed for a prolonged period, one may find organization of the lesions with peribronchial fibrosis and resultant emphysema.1

A fairly acute form of sarcoid with pulmonary lesions is clinically recognized, and it is sometimes accompanied by phenomena such as eosinophilia and erythema nodosum.2 These findings suggest an exudative type of lesion. The exact pathology in this phase has not been studied.

The commoner type of pathologic process seen in sarcoid is a noncaseating granuloma with a tendency toward tubercle formation. In ordinary practice the clinical diagnosis is usually confirmed by the finding of this type of lesion in a peripheral lymph node or, less frequently, by liver or skin biopsy. When in such cases pulmonary lesions and


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