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Menard M. Gertler, M.D.; Stanley M. Garn, Ph.D.; Paul D. White, M.D.
JAMA. 1951;147(7):621-625. doi:10.1001/jama.1951.03670240005002.
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A great deal has been achieved with modern diagnostic methods in the diagnosis of the acute or subacute phase of coronary heart disease which terminates in myocardial infarction. However, the increasing death toll from coronary heart disease suggests that still another form of approach to this problem be studied, namely, the prevention of coronary heart disease. It is obvious that before preventive measures are instituted recognition of the individual most prone to coronary heart disease will be necessary. Efforts should be made to determine which indivduals have the greatest tendencies to myocardial infarction. How can we recognize these putatively normal people in the entire population? To suggest a solution to this problem is the purpose of this presentation.

The ability to prevent disease is generally proportional to the knowledge of the etiological factors and pathogenesis of a disease. It is for these reasons that the problem of preselection of men


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