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DEATH FOLLOWING CURARE ADMINISTRATION

Harold Zimmerman, M.D.
JAMA. 1951;146(9):864. doi:10.1001/jama.1951.03670090096032.
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ABSTRACT

To the Editor:  —In view of the recent report by Foregger, "Fatalities Following Curare" (J. A. M. A. 142:1344 [April 29] 1950), I felt it would be timely and valuable to report a case of prolonged apnea and death following anesthesia supplemented with curare and syncurine® (decamethylene-1,10-bistrimethylammonium dibromide).On Feb. 13, 1950, a photographer, 53, underwent a gastric resection for duodenal ulcer. Other than the main complaint of obstruction and previous bleeding, there was nothing in this patient's history pertinent to this problem. There was no history suggestive of myasthenia gravis. Examination of the heart and lungs and chest x-ray disclosed no abnormalities. Premedication consisted of 1 mg. of dihydromorphinone hydrochloride and 0.40 mg. of atropine, given one hour before anesthesia was begun.The operation proceeded with somewhat greater than average difficulty, taking three hours and ten minutes. During this time, the blood pressure was well sustained except for

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