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James E. Pridgen, M.D.; Charles W. Mayo, M.D.; Arthur G. Steinberg, Ph.D.
JAMA. 1951;146(9):797-798. doi:10.1001/jama.1951.03670090029008.
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In reviewing the literature one finds that carcinoma of the small intestine forms from 0.029 per cent1 to 6 per cent2 of the gastrointestinal malignant lesions. After an exhaustive survey more than 550 cases of adenocarcinoma of the jejunum and ileum were found. However, only too rarely are carcinoid tumors segregated from primary carcinomas of the small intestine. Primary carcinoma of the small intestine exclusive of carcinoids was found to constitute about 1 per cent of the gastrointestinal malignant lesions in recent years at the Mayo Clinic.3 Even more unusual than the low incidence of this lesion is the occurrence of a familial tendency. Only one case of familial incidence was found among the 63 cases in which carcinoma of jejunum and ileum was surgically treated from 1907 through June 1947, at the Mayo Clinic; this series of cases is discussed elsewhere.4 Foster's description5 of


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