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John D. Pattison Jr., M.D.; Erwin Beck, M.D.; William B. Miller, M.D.
JAMA. 1951;146(9):783-787. doi:10.1001/jama.1951.03670090015005.
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Hypertrophic pulmonary osteoarthropathy, or hypertrophic osteoarthropathy, received its name from Pierre Marie in 1890, but was first described by Eugen Bamberger in 1889. As defined by Marie in 1890, it is a "symmetrical osteitis of the four limbs, chiefly localized to the phalanges and terminal epiphyses of the long bones of the forearm and leg, sometimes extending to the roots of the limb and flat bones, and accompanied by a dorsal kyphosis and some affection of the joints." This definition clearly differentiates hypertrophic osteoarthropathy from simple clubbing of the fingers and toes. Clubbing is a proliferative change of the soft tissues about the terminal phalanges with no constant osseous changes. It is believed by some1 to be the early stage of hypertrophic osteoarthropathy.

Hypertrophic osteoarthropathy, with rare exception,2 is secondary to an acute or chronic affection of the viscera. It is occasionally associated with conditions outside of the


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