This is a review of literature pertaining to the metabolic role of glucuronic acid. The senior author, formerly associate professor of biochemistry at Syracuse University, has been concerned with the subject for some time. The stated purpose of the authors is to bring presently available information together as a service and possibly as a stimulus to those who, in view of the fact that glucuronic acid is obtainable for the first time in sufficient amounts to permit exhaustive study, may wish to undertake investigation in this field.
Methods that have been employed for quantitative determination of glucuronic acid are described and discussed, and it appears that no completely satisfactory procedure has yet been developed. The compound is not found in the free state, but has been identified as a constituent of complexes such as heparin, hyaluronic acid, chondroitin and mucoitin sulfuric acids and of a number of immunopolysaccharides. It is