The availability and widespread clinical application of new and potent anticoagulant agents has made necessary the reevaluation of concepts of treatment of thromboembolic conditions. The published papers on this subject are numerous and are scattered in a wide variety of journals, making the task of evaluation difficult. The internist and surgeon will therefore welcome this monograph by Drs. Marple and Wright, which is an authoritative and critical review of this field. Before discussing the use of anticoagulant agents, the authors review, briefly but adequately, the occurrence and pathological physiology of venous thrombosis, pulmonary embolism and coronary occlusion. This section orients the reader in the field and emphasizes the relative importance and gravity of the various thromboembolic conditions.