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JAMA. 1951;145(11):825. doi:10.1001/jama.1951.02920290051013.
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The adrenal gland is unique in that it has one of the richest deposits of ascorbic acid of any organ. Also, there is a definite relation between the ascorbic acid content of the adrenal and the adrenocortical hormone concentration. It has been noted that on the administration of the pituitary adrenocorticotropic hormone (ACTH) to rats there is a decrease in the ascorbic acid concentration in the adrenals. Sayers and coworkers1 reported that under definite rigid conditions the degree of diminution of ascorbic acid in the adrenal could be used in the assay of adrenocorticotropic activity. It is also well known that there is a decrease in ascorbic acid content of the adrenals in scurvy. Hence, it is of interest to know whether there might be a decrease in the synthesis of adrenal steroids under the conditions imposed by deprivation of ascorbic acid.

Hyman and co-workers,2 using guinea pigs,


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