Greer1 recently prepared a review of the influence of foodstuffs on the metabolism of the thyroid. Of the various edible plants that have been shown to have an antithyroid action in animals, some members of the cabbage family and seeds of plants belonging to the family Brassicaceae (cabbage, rape and the mustards) are of most interest. Chesney, Clawson and Webster2 have shown that cabbage produces goiter in rabbits. In the course of a study on experimental syphilis, they noted that the animals developed pronounced goiter, and after checking the various factors involved they concluded the antithyroid material was present in the cabbage in the diet. Since then, goiters have been produced experimentally in rabbits and in other species.
The production of hyperplasia of the thyroid by feeding cabbage has not yielded completely uniform results, since the goitrogenic power of the plant appears to vary according to the season,