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Lester Hollander, M.D.
JAMA. 1940;115(26):2271-2272. doi:10.1001/jama.1940.72810520001009.
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Mrs. R. H., aged 49, an American housewife, referred to me by Dr. Charles E. Hays of Johnstown, Pa., on May 7, 1940, presented a sharply defined, vesiculo-erythematous eruption which involved the nose, the upper lip and the adjacent portion of the right lower eyelid. The tip of the nose and the central furrow of the upper lip were thickened and cracked, these being the areas of the most marked involvement. The eruption was of approximately four months' duration and it was exceedingly itchy.

It was evidently due to some sensitizing contact substance, but neither the history of the onset and course nor any variability in the intensity of the subjective symptoms gave me any clue except that the substance had something to do with the face and especially with the nose.

Accordingly the patient was instructed to stop the use of her cosmetics, soap, handkerchiefs and cleansing tissues for


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