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Alexander Winter, M.D.
JAMA. 1940;115(24):2103-2104. doi:10.1001/jama.1940.02810500071031.
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To the Editor:—  I wish to report my limited experience on the use of prostigmine in delayed menstruation. My results are not as favorable as those reported in the article of Soskin, Wachtel and Hechter in The Journal, May 25, on "Treatment of Delayed Menstruation with Prostigmine: A Therapeutic Test for Pregnancy."Stimulated by the fine reports in the aforementioned article and the promotion of prostigmine methylsulfate by Hoffmann-LaRoche, I decided to use the test on a small number of private patients. The 4 cases tabulated give sufficient indication that their conclusions in only a small series of 25 cases are incorrect. Four interesting variations occurred, tending to indicate that prostigmine cannot be relied on as a test in a presenting case for diagnosis. The authors' statement "If she fails to menstruate, pregnancy may be diagnosed with the same degree of accuracy as in the Friedman test" is not


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