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TREATMENT OF DIABETES

Elliott P. Joslin, M.D.; Howard F. Root, M.D.; Priscilla White, M.D.; Alexander Marble, M.D.
JAMA. 1940;115(12):1038-1039. doi:10.1001/jama.1940.02810380068027.
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ABSTRACT

To the Editor:—  It was with dismay that we read in The Journal, August 10, statements of Dr. Edward Tolstoi at a conference of "the members of the Departments of Pharmacology and of Medicine of Cornell University Medical College and the New York Hospital, with the collaboration of other departments" regarding the treatment of diabetes. He said:We found that our experimental subjects were free from the symptoms of diabetes in spite of glycosuria when they were receiving a diet of 75 Gm. of protein, 60 Gm. of fat and 200 Gm. of carbohydrate, and protamine zinc insulin in daily doses of 50 units. Two rather unusual patients whom we observed in the metabolism ward for periods of fifty to sixty days maintained their weight. I want to emphasize this point. They also had no thirst or polyuria; they had no ketonuria, and they were in nitrogenous equilibrium in spite

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