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VERTEBRAL FRACTURES AS A COMPLICATION OF CONVULSIONS: IN HYPOGLYCEMIC SHOCK AND METRAZOL THERAPY IN PSYCHIATRIC DISORDERS

PHILLIP POLATIN, M.D.; MURRAY M. FRIEDMAN, M.D.; MEYER M. HARRIS, M.D.; WILLIAM A. HORWITZ, M.D.

JAMA. 1940;115(6):433-436. doi:10.1001/jama.1940.02810320013005.

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In a previous communication we presented the frequent complication of vertebral fractures in the course of metrazol therapy in psychiatric disorders.¹ At that time, in a roentgenographic study of fifty-one psychiatric patients who had received treatment with metrazol, twenty-two (43.1 per cent) manifested compression fractures of the vertebrae, most commonly in the midthoracic region, and in most instances the fractures of the vertebral bodies were multiple. Fragmentation and compression of the anterior portion of the upper surface of the body occurred frequently, while in about half the cases the fractures manifested themselves only by a slight forward displacement of a disklike fragment of the upper portion of the body. There was a higher incidence of fractures in female (sixteen) than in male (six) patients.

At the time of the first report it was indicated that a study was being made of the effect of keeping the patient on his

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POLATIN P, FRIEDMAN MM, HARRIS MM, HORWITZ WA. VERTEBRAL FRACTURES AS A COMPLICATION OF CONVULSIONS: IN HYPOGLYCEMIC SHOCK AND METRAZOL THERAPY IN PSYCHIATRIC DISORDERS. JAMA. 1940;115(6):433-436. doi:10.1001/jama.1940.02810320013005.

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VERTEBRAL FRACTURES AS A COMPLICATION OF CONVULSIONS: IN HYPOGLYCEMIC SHOCK AND METRAZOL THERAPY IN PSYCHIATRIC DISORDERS

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