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JAMA. 1940;115(6):429-432. doi:10.1001/jama.1940.02810320009004.
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The discovery by Best and McHenry1 of an enzyme which specifically inactivates histamine suggests its use in the treatment of allergic cutaneous disorders. It has been shown that there is a release of so-called H substance in the blood during allergic shock and that this H substance may be histamine. Innumerable writers have endeavored to demonstrate the fact that histamine must be the trigger mechanism which prepares the skin for various reactions, particularly the so-called triple response of vasodilatation (streak), wheal exudative (edema) and reflex nervous dilatation (flare), which is dermatographism or urticaria itself.2 If this fact is true, then the assumption that treatment of these allergic states with histaminase is well founded and worthy of an extended trial before being discarded as another false hope in the long list of attempts to combat the allergic dermatoses.

Histamine may be obtained from the liver, lungs, skin and other


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