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HEMATURIA FROM SULFATHIAZOLE THERAPY IN PNEUMONIA

John H. Arnett, M.D.
JAMA. 1940;115(5):362-363. doi:10.1001/jama.1940.72810310003007a.
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The tendency of sulfapyridine to form urinary crystals resulting in hematuria and even obstruction is by this time well known. Gross, Cooper and Scott1 have collected from the literature thirty-six cases of gross hematuria, with seven in which uroliths were specifically mentioned, complete bilateral ureteral block being disclosed at autopsy in one instance.2 Plummer and McLellan3 have reported two cases of unilateral calculus formation, one of which was fatal. Arnett, Shoup and Henry4 have reported a case of bilateral ureteral obstruction with recovery. The fact that similar complications can arise in the course of sulfathiazole therapy is now beginning to be recognized. Gross, Cooper and Scott1 have demonstrated concretions in the kidneys of rats receiving sulfathiazole, and Pepper and Horack5 reported the death of a 77 year old pneumonia patient who developed hematuria and oliguria while on sulfathiazole therapy. At autopsy the kidneys were

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