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SUBCONJUNCTIVAL INJECTION OF CORTISONE IN IRITIS

RAPHAEL KOFF, M.D.; SOL ROME, M.D.; RICHARD KASPER, M.D.; ROBERT R. COMMONS, M.D.; RICHARD BUTTON, M.D.; PAUL STARR, M.D.
JAMA. 1950;144(15):1259-1260. doi:10.1001/jama.1950.62920150004009a.
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The purpose of this report is to demonstrate a practical, inexpensive method of utilizing cortisone for treatment of diseases of the eye. The method avoids the undesirable side effects sometimes seen with systemic administration of pituitary adrenocorticotropic hormone (ACTH) or cortisone.

METHOD  The conjunctiva is anesthetized with tetracaine (pontocaine®) hydrochloride. A pledget of 10 per cent cocaine is then placed on the bulbar conjunctiva at the site of the injection, usually at 12:00 o'clock, 5 to 6 mm. from the upper limbus. Cortisone acetate,1 0.2 to 0.4 cc. (25 mg. per cubic centimeter), is then injected subconjunctivally with a 23 gage needle. Subsequent injections when indicated are administered at different sites. The procedure is repeated in 48 or 72 hours if necessary.

RESULTS  Figure 1 shows the results in nine cases of acute or acute recurrent iritis. The shaded portions represent the condition before the cortisone administration. The unshaded

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