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August 27, 1949, Vol 140, No. 17 >

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ARTICLE | August 27, 1949

FATE OF INSULIN IN THE NORMAL AND DIABETIC ORGANISM

JAMA. 1949;140(17):1344. doi:10.1001/jama.1949.02900520030012.
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Little has been known of the ultimate fate of insulin in the human organism. Obviously, insulin is constantly being eliminated; otherwise cumulative effects manifested by periods of severe hypoglycemia would be observed even in normal subjects. As is well known, however, the blood sugar level is maintained remarkably constant in normal persons. At least two different methods of disposing of insulin appear possible: one by excretion in the urine or possibly feces (via bile) and the other by destruction in the body. The first route, that of excretion, would not appear to be of major importance. The elimination of protein molecules as large as that of insulin (molecular weight 35,000) seldom takes place to any significant extent in the normal kidney and probably not in the bile or feces. Support for this statement is to be found in a recent study1 in which it was reported that the urine

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