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August 6, 1949, Vol 140, No. 14 >
ARTICLE | August 6, 1949

COMMITTEE OF THE NATIONAL ACADEMY OF SCIENCES ON THE INVESTIGATION OF CORTISONE

JAMA. 1949;140(14):1158. doi:10.1001/jama.1949.02900490024009.
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ABSTRACT

The recent report by Hench, Kendall, Slocumb, and Polley of the dramatic effectiveness of the adrenal cortical steroid, Cortisone (first isolated by E. C. Kendall), in the treatment of rheumatoid arthritis developed the difficult problem of distributing the limited amount of the substance obtainable for the rest of 1949. Originally obtained from the cortex of the adrenal gland, Cortisone is now being prepared from a bile acid. While the value of Cortisone in controlling the symptoms of rheumatoid arthritis is regarded as established, much remains to be learned concerning its possible untoward effects, its usefulness in other diseases and the mechanism of its action. The small amount which can be made during the last five months of 1949 will be used only for clinical and experimental research and will be made available to those investigators who may best provide the information needed to insure its safe and effective use.

The

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BMJ 2010;341:c5893-c1494.
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