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July 9, 1949, Vol 140, No. 10 >
ARTICLE | July 9, 1949

SEX DETERMINATION

Frederick Hoelzel; Anton J. Carlson, Ph.D., M.D.
JAMA. 1949;140(10):908-909. doi:10.1001/jama.1949.02900450058020.
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ABSTRACT

To the Editor:—  In reply to a request for an explanation of the fact (?) that the sex of the offspring is that of the relatively stronger parent, it was maintained in The Journal (May 28, 1949) that this has nothing to do with the determination of sex. The chromosomal explanation of sex determination was presented and the birth of about 94 females to every 100 males was cited as evidence in support of this explanation. However, approximately as many males as females would also be born if a number of factors besides the chromosomes influenced sex determination and under ordinary or uncontrolled conditions did so on a purely chance basis. As a matter of fact, human sex ratios have been reported which support the view that the sex of the offspring tends to be that of the "superior" parent. Thus, a ratio of 149 males to 100 females (5,676 males

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