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July 9, 1949, Vol 140, No. 10 >
ARTICLE | July 9, 1949

THE RELATIONSHIP OF TRYPTOPHANE AND NICOTINIC ACID

JAMA. 1949;140(10):876. doi:10.1001/jama.1949.02900450026008.
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The name of Dr. Joseph Goldberger inevitably comes to mind in any discussion of the causation, prevention and cure of pellagra. He pioneered in the attempts to associate the appearance of the disease with causative nutritional factors; as he continued his studies he repeatedly showed the parallelism between presence or absence of pellagra and differences in the diet of the persons under examination. Particularly was the consumption of proteins of recognized superior biologic value regularly associated with the absence of the disease. In 1937 Elvehjem and his co-workers1 demonstrated that nicotinic acid prevented and cured the canine analogue of human pellagra, and its efficacy in treating pellagra in man was promptly demonstrated.2 The earlier suggestion that protein of high nutritional value exerted a favorable effect on human pellagra and the discovery of the curative properties of nicotinic acid were partially harmonized by the observation that, in the rat,

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