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ARTICLE | July 9, 1949

PERORAL ADMINISTRATION OF UNDECYLENIC ACID IN PSORIASIS

H. HARRIS PERLMAN, M.D.; IRVING L. MILBERG, M.D.

JAMA. 1949;140(10):865-868. doi:10.1001/jama.1949.02900450015004.

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In recent years, certain fatty acids have been found to exert antifungal activity on the human skin and to be valuable in both prevention and treatment of some of the superficial dermatomycoses.¹ As far as we have been able to discover, practically nothing is known to date about the pharmacologic, toxicologic and therapeutic potentialities of the oral administration of these acids. However, previous studies² appear to justify the assumption that a portion of an ingested amount of certain fatty acids may retain chemical characteristics in the fat of the tissue and in the sebum. The selection of an unsaturated acid appeared of special interest for the purposes of the present studies.

Our first attempts were designed to investigate the possibility that the oral administration of undecylenic acid might have a therapeutic effect on recalcitrant fungous infections, in particular on tinea capitis (Microsporon audouini) and on onychomycosis.

Preceding its

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PERLMAN H, MILBERG IL. PERORAL ADMINISTRATION OF UNDECYLENIC ACID IN PSORIASIS. JAMA. 1949;140(10):865-868. doi:10.1001/jama.1949.02900450015004.

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