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June 25, 1949, Vol 140, No. 8 >
ARTICLE | June 25, 1949

POSTONCOLYTIC IMMUNITY

JAMA. 1949;140(8):683-684. doi:10.1001/jama.1949.02900430025011.
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In 1946 Aptekman1 and his associates of the Wistar and Carnegie Institutes prepared an alcoholic extract of rat sarcoma tissues. Concentrates of this extract injected into transplanted sarcomas in homologous inbred strains of rats caused a rapid lysis of the sarcomas, followed by sloughing and complete healing. Tested several weeks or months later the recovered rats were found to be wholly refractory to reimplantations with homologous type sarcoma.

Confirmation of this postoncolytic tumor immunity with attempted determination of the chemical nature of the specific oncolysin is currently reported by the same investigators.2 Primary sarcomas were induced in various inbred strains of rats by a local injection of 3 mg. methylcholanthrene dissolved in mineral oil. Tumors thus induced were found to be 100 per cent transplantable to rats of the same inbred strain. Grafts from these primary tumors implanted into 1 month old susceptible rats of homologous strain usually

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