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June 25, 1949, Vol 140, No. 8 >
ARTICLE | June 25, 1949

SOME EFFECTS OF MYANESIN® IN PSYCHIATRIC PATIENTS

LOUIS S. SCHLAN, M.D.; KLAUS R. UNNA, M.D.
JAMA. 1949;140(8):672-673. doi:10.1001/jama.1949.02900430014005.
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The drug 3-ortho-toloxy-1,2-propanediol (myanesin,® tolserol®)1 was introduced by Berger and Bradley2 as a muscle-relaxing agent; it apparently raises the threshold of internuncial neurons in the spinal cord and brain stem.3 Myanesin® does not affect voluntary muscle power, is not hypnotic and has negligible effects on the electroencephalogram in doses of 0.5 to 2.0 Gm. given by mouth four to five times a day. It has been used to alleviate spasticity and rigidity with variable results.4 It has also been tried in cases of intractable pain5 and in 3 psychotic patients.5b

Its use in the treatment of anxiety was suggested to us by Dr. Pauline Cooke of Chicago. Sixty-three patients (from Manteno State Hospital) were chosen to test its effects not only in anxiety states but also in acute and chronic psychoses (mixed types of schizophrenia), in alcoholism, in addiction to drugs and as an

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