Irving B. Brick, M.D.
JAMA. 1956;160(13):1168. doi:10.1001/jama.1956.02960480068019.
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To the Editor:—  In Dr. Boland's article, "Prednisone and Prednisolone Therapy in Rheumatoid Arthritis," appearing in the Feb. 25, 1956, issue of The Journal, page 613, a comparison of these two medicaments with hydrocortisone is made. I wish only to comment on the ulcerogenic properties of these medicaments, which the author found to be increased by the use of prednisone and prednisolone. My experience with the latter two medicaments is based on the treatment of ulcerative colitis, regional enteritis, and liver disease. I have not found an alarming incidence of peptic ulcer or digestive complaints in my patients, most of whom have had an upper gastrointestinal x-ray study prior to administration of therapy. Perhaps the nature of the patients treated by Dr. Boland and the procedure of study should be further analyzed. In common with most studies printed on the ulcerogenic properties of steroid therapy, control gastrointestinal x-ray studies were


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