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June 11, 1949, Vol 140, No. 6 >
ARTICLE | June 11, 1949

EFFECT OF URECHOLINE® ON THE STOMACH, INTESTINE AND URINARY BLADDER

I. F. STEIN, M.D.; KARL A. MEYER, M.D.
JAMA. 1949;140(6):522-525. doi:10.1001/jama.1949.02900410018005.
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Recent interest has been aroused in the drug urecholine®1 (urethane of beta methylcholine chloride) by the demonstration of the stimulatory action of this drug on gastric motility following complete vagotomy. This action was first reported by Machella 2 and confirmed by Grimson,3 Stein,4 Smith5 and Dragstedt.6 Starr and Ferguson7 have reviewed the early literature and have demonstrated the value of urecholine® in postoperative urinary retention. The stimulatory effect of urecholine® on intestinal motility was reported by Youmans 8 and has been further studied experimentally by Postlethwait.9

METHOD  The effect of urecholine® on the stomach was studied by means of kymographic tracing of gastric motility as well as clinical observations. A detailed report of the gastric motility studies was previously published.10The effect of urecholine® on intestinal motility was studied by clinical observation of patients with adynamic ileus. The effect of urecholine® on

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