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Phillip Comens, M.D; Henry A. Schroeder, M.D.
JAMA. 1956;160(13):1134-1136. doi:10.1001/jama.1956.02960480034008b.
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A syndrome simulating collagen disease has been reported in some patients receiving hydralazine (Apresoline) hydrochloride for at least six months in order to control arterial hypertension. The typical L. E. cell has sometimes been found in the peripheral blood of such individuals, especially when administration of the drug was continued after the appearance of arthralgia or arthritis.111 Symptoms at first resembled rheumatoid arthritis of various degrees of severity; in more advanced forms manifestations of disseminated lupus erythematosus appeared. This report represents the first of a series designed to study the action of hydralazine in relation to collagen disease. A second will be concerned with the production of a similar syndrome in dogs.


Two hundred thirty-six L. E. preparations were made on blood from 105 hypertensive patients receiving hydralazine. Ninety-seven patients had no symptoms of arthritis, and eight had arthritis plus the physical and laboratory abnormalities that are associated with


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