Asher Winkelstein, M.D.; Eric Schweiger, M.D.
JAMA. 1956;160(13):1111-1113. doi:10.1001/jama.1956.02960480011003.
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• A fluid nutriment (Sustagen) of known carbohydrate, fat, protein, mineral, vitamin, and known caloric content was tested to determine whether its effects on gastric acidity might render it useful in patients with various gastric secretory disturbances.

Sustagen provoked less secretion of acid than did a test meal of crackers and water in 10 patients. It suppressed the secretion of free acid in response to histamine in four patients. A group of four patients took it alternately with milk on successive days; gastric analyses showed that the Sustagen caused more complete and prolonged reduction of acidity than did the milk. A group of six patients who had been suffering from the distressing symptoms of prolonged nocturnal hyperchlorhydria received Sustagen by continuous intragastric drip, which completely abolished the free acidity during the night.


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