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STREPTOMYCIN

JAMA. 1949;140(5):478-479. doi:10.1001/jama.1949.02900400032011.
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In 1944, Herrell reported that "a rather striking suppressive effect on the course of tuberculosis of guinea pigs was obtained" by treating the animals with streptomycin at varying intervals. As nearly as arbitrary numerals could express it, the tuberculosis index of infection controls was 81.9 as compared with 2.8 for the treated.1 At the time streptomycin was said to have a suppressive effect on human tuberculosis infection in guinea pigs in addition to being well tolerated by the animals. However, not all early students were so enthusiastic.2 In the fall of 1946 and after it had been demonstrated that streptomycin had definite therapeutic potentialities in the treatment of clinical tuberculosis, large quantities of streptomycin became available for clinical tests. Such tests were urgent because of the numerous reports of cures and for the purpose of determining (1) the types of pulmonary tuberculosis most likely to benefit from the

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