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May 14, 1949, Vol 140, No. 2 >
ARTICLE | May 14, 1949

THE TREATMENT OF THYROTOXICOSIS

I. S. RAVDIN, M.D.; EDWARD ROSE, M.D.; JAMES D. MAXWELL, M.D.
JAMA. 1949;140(2):141-146. doi:10.1001/jama.1949.02900370009004.
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Within the past few years a number of important advances have been made in our knowledge of the normal and abnormal functioning of the thyroid gland. These advances have resulted in part from the introduction of new methods for the treatment of thyrotoxicosis. It would seem desirable at this time to reexamine the present methods of treating thyrotoxicosis with special consideration of the status of thyroidectomy.

The most important recent advances in the knowledge of thyroid physiology have resulted from the use of three major tools: (1) a large group of goitrogenic compounds, varying considerably in chemical structure and mode of action (sulfonamide compounds, thiourea derivatives, sulfocyanates); (2) radioactive iodine and (3) relatively purified preparations of the thyrotropic hormone of the anterior pituitary. From the integrated use of these tools much has been learned concerning the mode of transport of inorganic iodine to the thyroid; the mechanism of its entrapment,

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