0
April 30, 1949, Vol 139, No. 18 >

Full Content is available to subscribers

Subscribe/Learn More
ARTICLE | April 30, 1949

USE OF MIXTURES OF SULFONAMIDE DRUGS

Solomon Garb, M.D.; Lawrence A. Janoff, M.D.
JAMA. 1949;139(18):1294-1295. doi:10.1001/jama.1949.02900350056022.
Text Size: A A A
Published online
Article

ABSTRACT

To the Editor:—  In their letter to the Editor of Dec. 4, 1948, Drs. Reinhold and Flippin commented that the figure of 6 Gm. excretion of acetylated sulfonamide compound which we assumed for purposes of calculation in our letter of Oct. 2, 1948, was exceedingly high. In our original communication we stated that this figure was used for the sake of simplicity. We concede that it is too high. Nevertheless, it can be shown that the reduction in crystalluria to be expected from the use of sulfonamide mixtures is small, using the figures given by Drs. Reinhold and Flippin for absorption and acetylation.They state that 4 Gm. of sulfonamide compound would be absorbed and 10 to 50 per cent acetylated. Let us first calculate the amount of sulfonamide compound to be excreted as crystals when 10 per cent is acetylated, assuming a urinary pH of 5.5 and a

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

Letters

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs

More Listings at
JAMACareerCenter.com >

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems