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April 30, 1949, Vol 139, No. 18 >
ARTICLE | April 30, 1949

ADRENAL CORTICAL HORMONE FOR ARTHRITIS

Merck & Co., Inc.
JAMA. 1949;139(18):1294. doi:10.1001/jama.1949.02900350056021.
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ABSTRACT

To the Editor.—  Drs. P. S. Hench, E. C. Kendall, C. H. Slocumb and H. F. Polley of the Mayo clinic and Mayo Foundation have studied the effects of an adrenal cortical hormone (compound E), which appears to give some promise of relief in certain forms of arthritis. (Proc. Staff. Meet., Mayo Clin.24: 181 [April 13] 1949). For the past several years Merck & Co., Inc., has been privileged to participate in this project by collaboration with Dr. E. C. Kendall and under an agreement with the Research Corporation. Compound E was first synthesized in the Merck Research Laboratories, and the details of this synthesis were published in the March 1946 issue of the Journal of Biological Chemistry. We have supplied from the limited amounts available the greater part of Compound E for Dr. Hench's clinical work during the past eight months.It is expected that the publication of

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