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April 30, 1949, Vol 139, No. 18 >
ARTICLE | April 30, 1949

SOME BASIC PRINCIPLES AND PROBLEMS OF CLINICAL ALLERGY

FRANK A. SIMON, M.D.
JAMA. 1949;139(18):1258-1259. doi:10.1001/jama.1949.02900350020005.
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ABSTRACT

It is not the purpose nor is it possible in this presentation to consider most or even many of the known facts and unsolved problems of clinical allergy. Rather it is my hope to consider briefly some of the more important and more fundamental aspects of the known and the unknown in clinical allergy. In a relatively new and rapidly developing field it is natural that there should be some controversy and honest differences of opinion. It is only with more time and more careful work that such differences can at least partially be resolved. Without going into a philosophic definition of knowledge, I think it necessary to point out that the line of cleavage between the true and the false in clinical medicine is sometimes not as sharp as one would like to have it but that it often seems to consist of different degrees of probability. Pragmatically, this

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