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Conditioned Reflexes and Neuron Organization

JAMA. 1949;139(15):1045. doi:10.1001/jama.1949.02900320075040.
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ABSTRACT

This is the most recent publication on neurophysiology and is excellent. The author worked for many years under the guidance of Pavlov in Leningrad. He has attempted to extend the Sherrington conception of the functioning of the nervous system to the field of higher nervous activity. This was done on the basis of enormous experimental material collected by the Pavlov school. Konorski believes that the doctrine of Pavlov is not entirely correct and has accepted the Sherrington principle of neuron excitation with a few reservations. The author has assumed that the elaboration of a conditioned reflex consists in the formation of new functional connections in the brain. Further, he states that if a combination of excitations which results in aplastic change is not repeated a greater or lesser regression of this change occurs (atrophy of the synaptic connections. Further, he assumes that internal inhibition consists in the formation of new

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