We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |


Edwin L. Prien, M.D.; Burnham S. Walker, M.D.
JAMA. 1956;160(5):355-360. doi:10.1001/jama.1956.02960400013004.
Text Size: A A A
Published online


• Glucuronides increase the solubility of calcium phosphate. Excretion of glucuronides in the urine can be increased by administering compounds, such as the salicylates, that conjugate with glucuronic acid.

Acetylsalicylic acid was therefore given orally to a series of patients with frequently recurring calcium-containing calculi. One patient had passed approximately 100 calculi in 14 years, and 12 patients had collectively undergone 23 major operations for removal of calculi. All patients in this series had had a "stone episode" within a year of starting treatment or had renal calculi in situ at the time. In addition to 2 gm. of acetylsalicylic acid, treatment included liberal water and low-calcium intake.

It was almost always possible to double the pretreatment urinary output of glucuronides; sometimes it was tripled or quadrupled. Salicylamide proved even better than acetylsalicylic acid and is used in all cases now. In 17 out of 19 patients there was no recurrence of calculi. In one patient there was recurrence, and in another some preexisting calculi increased slightly in size. The therapy prevented the common incrustation of inlying catheters in eight out of nine patients whose catheters previously became obstructed in one or two weeks. Salicylates are recommended for further trial as means for preventing recurrence of calcium-containing urinary calculi.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.