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William C. Keettel, M.D.; Raymond G. Bunge, M.D.; James T. Bradbury, Sc.D.; Warren O. Nelson, Ph.D.
JAMA. 1956;160(2):102-105. doi:10.1001/jama.1956.02960370012003.
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• In the infertile women the most frequent findings were menstrual irregularity and endometriosis. In the men, examination of the semen revealed azoospermia in more than an eighth of the cases studied. Instances of nonliquefying semen were found, but insemination with material liquefied by alphaamylase was not followed by conceptions.

The treatment of infertility was more successful in the cases that involved the female partner. In some instance pregnancy followed shortly after tubal insufflation, but a causal relationship could not be proved. Conceptions followed artificial insemination with either fresh or frozen material. The frequency of obstetric complications was not increased above the usual figures in this series.


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