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February 26, 1949, Vol 139, No. 9 >
ARTICLE | February 26, 1949

DIAGNOSIS OF CANCER

JAMA. 1949;139(9):586-587. doi:10.1001/jama.1949.02900260032009.
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A recent article in the Scientific American contains deprecatory remarks on the histologic diagnosis of tumors and other statements which are contrary to current medical opinion.1 Supporting scientific data are not supplied. The lessening of confidence in the value of biopsy and microscopic study which may result from the article needs to be condemned. Microscopic examination for diagnosis of tumor is not infallible. The methods need to be constantly improved, and additional supplementary diagnostic methods should be sought. Nevertheless such examination is today still one of the most useful diagnostic procedures, and in many instances the most exact practical method of diagnosis.

The article under discussion deals with the heterotransplantation of tissue as a test for cancer. In performing this test small pieces of tissue are implanted into the anterior chamber of the eye of an alien species of animal—generally the guinea pig or rabbit. If the cells are

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BMJ 2010;341:c5893-c1494.
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