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February 12, 1949, Vol 139, No. 7 >
ARTICLE | February 12, 1949

THE JOSEPH GOLDBERGER AWARD IN NUTRITION

JAMA. 1949;139(7):459-460. doi:10.1001/jama.1949.02900240037011.
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Until recently progress had been slow in efforts to define chemically the active anti-pernicious-anemia principle of liver. The absence of a suitable experimental analogue to pernicious anemia has made it necessary to test various chemical fractions by laborious clinical assay. Now another assay has been devised, a microbiologic technic, for anti-pernicious-anemia potency. This method is yet in the developmental stage. Few clinical investigators have had the patience to study the activity in the human being of fraction after fraction from liver over the long interval necessary for the successful concentration of the active principle.

Within a year after Minot and Murphy's report1 of the successful treatment of pernicious anemia with a diet containing large quantities of liver, Dr. Randolph West2 embarked on an attempt to concentrate the active principle from liver. Dr. West's continuous interest in this problem is attested by repeated publications with various collaborators during the

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