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February 12, 1949, Vol 139, No. 7 >
ARTICLE | February 12, 1949

REACTIONS TO PERTUSSIS VACCINE

JOHN A. TOOMEY, M.D.
JAMA. 1949;139(7):448-450. doi:10.1001/jama.1949.02900240026006.
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The report of Byers and Moll1 on irreversible reactions following the injection of pertussis vaccine was disturbing, since prior to it this antigen had been considered innocuous. Their observations cover a ten year period and are summarized in table 1.

In case 2, 1 of 2 siblings had epilepsy and an uncle had hydrocephalus; in case 9, 1 of 2 siblings had hydrocephalus, and in case 12, 1 patient had febrile convulsions. No cases appeared between 1940 and 1942; 1 to 4 cases were seen during each of the other years. Twelve patients had received fluid toxoid. Five had reactions after the first, 4 after the second and 6 after the third dose. Two died and 8 had irreversible cerebral damage. The dose for 4 patients was unknown. Six of the remaining 12 had been given from 40 to 45 billion, 3 had 30 billion and 2 had 10

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