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February 5, 1949, Vol 139, No. 6 >
ARTICLE | February 5, 1949

DOSAGE OF D-TUBOCURARINE IN WAX AND OIL

H. Sidney Newcomer, M.D.; E. R. Squibb & Sons.
JAMA. 1949;139(6):397. doi:10.1001/jama.1949.02900230051021.
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ABSTRACT

To the Editor:—  A serious error has been made in the article by Weed, Purvis and Warlike on "d-Tubocurarine in Wax and Oil for Control of Muscle Spasm in Tetanus," published in The Journal on Dec. 11, 1948 (138:1087). The statement is made: "Each cubic centimeter of this preparation contains 175 mg. of d-tubocurarine in 4.8 per cent wax in peanut oil." This statement should read: "Each cubic centimeter contains 27 mg. d-tubocurarine chloride pentahydrate (equivalent to 180 units) and 48 mg. of myricin (wax) suspended in peanut oil." (This statement describes our present market product but it is probable that the authors used 175 unit material as distributed for clinical investigation.) Throughout the text reference to dosage is made in terms of milligrams rather than units and is based on the original error describing the product.We are concerned about this because we have had telephone calls asking

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