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February 5, 1949, Vol 139, No. 6 >
ARTICLE | February 5, 1949

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JAMA. 1949;139(6):382. doi:10.1001/jama.1949.02900230036013.
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FLUORINE VERSUS DENTAL CARIES  Attempts to determine the value of fluorine in the prevention of dental caries in rats are reported by Cheyne1 of the College of Dentistry, University of Iowa. Since McClure2 and others have presented data which show that significant reduction in the incidence of induced dental caries in rats is not demonstrable as a result of postnatal applications of fluorine, Cheyne limited his study to the effects of prenatal fluorinization. Eighteen young rats were obtained from mothers which had received daily administrations of potassium fluoride during pregnancy. As controls, 27 young were selected from mothers which had not received fluorine. Half of the fluorinized (mottled teeth) young and 12 of the 27 nonfluorinized young were subjected to total extirpations of the salivary glands3 at the age of 24 days. On the forty-second day all animals were placed on a caries-producing diet,4 without restriction

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