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February 5, 1949, Vol 139, No. 6 >
ARTICLE | February 5, 1949

HODGKIN'S DISEASE

JAMA. 1949;139(6):380-381. doi:10.1001/jama.1949.02900230034011.
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An increased number of cases of Hodgkin's disease has apparently been reported during the last twenty years.1 The increase is considered by some investigators to be due to a wider use of biopsies as a diagnostic measure. However, the Metropolitan Life Insurance Company figures which compare statistics for 1921 and 1936 appear to support the opinion that the disease is increasing, while the statistics of the New York City Department of Health appear to deny it. The incidence of Hodgkin's disease in the United States was recently reported2 to vary from 0.5 to 2.5 per 100,000 population.

Malpighi wrote the first description of Hodgkin's disease in 1661. Thomas Hodgkin recognized the syndrome as a clinical entity in 1832 and described 7 cases with lymph node and splenic enlargement, cachexia and a fatal termination. Langhans noted giant cells in the lesions in 1872. In 1892, Goldman pointed out that

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