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William H. Olson, M.D.; Heinrich Necheles, M.D., Ph.D.
JAMA. 1955;159(10):1013-1014. doi:10.1001/jama.1955.02960270033009.
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We have reported that in the dog gastric secretion and motility are depressed considerably during the first 30 minutes after injection of insulin. Recently, we have described a similar observation on the gastric secretion of patients with active duodenal ulcer. It was felt to be necessary to confirm the latter results in a comparable group of normal subjects. The stomach of a patient with active duodenal ulcer appears to be in a state of irritability and of secretory stimulation. Therefore, results obtained in such patients need not be applicable to normal subjects.


Thirty-three healthy male prisoners volunteered as subjects for the test. Their ages varied between 25 and 54 years, with an average age of 40 years. A careful history was taken and physical examination was given in order to exclude disease, particularly peptic ulcer. Persons who at any time had taken baking soda or other drugs used in ulcer


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